GGPS1 and ATOX1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GGPS1	ATOX1
Description		geranylgeranyl diphosphate synthase 1	antioxidant 1 copper chaperone
Image
GO Annotations	Cellular Component	Cytosol	Cell Cytosol
	Molecular Function	Dimethylallyltranstransferase Activity Farnesyltranstransferase Activity Geranyltranstransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding ATPase Binding
	Biological Process	Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Geranyl Diphosphate Biosynthetic Process Geranylgeranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process	Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress Negative Regulation Of Apoptotic Process Copper Ion Export
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface
Drugs		Zoledronic acid Geranyl Diphosphate FARNESYL THIOPYROPHOSPHATE ISOPENTENYL PYROPHOSPHATE (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)	Cisplatin Sucrose Benzamidine
Diseases
GWAS		Asthma ( 29273806)	Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Systolic blood pressure change trajectories ( 27980656)
Interacting Genes		1 interacting genes: ATOX1	6 interacting genes: ATP7A ATP7B CFAP410 FAM118A FKBP4 GGPS1
Entrez ID		9453	475
HPRD ID		06099	03779
Ensembl ID		ENSG00000152904	ENSG00000177556
Uniprot IDs		O95749	O00244
PDB IDs		2Q80 6C56 6C57 6G31 6G32 6R4V	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L
Enriched GO Terms of Interacting Partners?
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