ATOX1 and ATP7A

Number of citations of the paper that reports this interaction (PubMedID 10557326)
65

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vivo)

		ATOX1	ATP7A
Description		antioxidant 1 copper chaperone	ATPase copper transporting alpha
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GO Annotations	Cellular Component	Cell Cytosol	Cell Nucleus Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Microvillus Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Phagocytic Vesicle Membrane Cell Leading Edge Brush Border Membrane Neuron Projection Neuronal Cell Body Perikaryon Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding ATPase Binding	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding Superoxide Dismutase Copper Chaperone Activity Copper-dependent Protein Binding Copper-transporting ATPase Activity Rac GTPase Binding Chaperone Binding Cuprous Ion Binding
	Biological Process	Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress Negative Regulation Of Apoptotic Process Copper Ion Export	Blood Vessel Development In Utero Embryonic Development Liver Development Blood Vessel Remodeling Regulation Of Oxidative Phosphorylation Tryptophan Metabolic Process Catecholamine Metabolic Process Copper Ion Transport Cellular Copper Ion Homeostasis Mitochondrion Organization Lactation Locomotory Behavior Response To Iron(III) Ion Response To Manganese Ion Response To Zinc Ion Detoxification Of Copper Ion Regulation Of Gene Expression Positive Regulation Of Lamellipodium Assembly Copper Ion Import Peptidyl-lysine Modification Removal Of Superoxide Radicals Antimicrobial Humoral Response Cerebellar Purkinje Cell Differentiation Pyramidal Neuron Development Central Nervous System Neuron Development Extracellular Matrix Organization Collagen Fibril Organization Hair Follicle Morphogenesis Ion Transmembrane Transport Negative Regulation Of Iron Ion Transmembrane Transport Cellular Response To Platelet-derived Growth Factor Stimulus T-helper Cell Differentiation Epinephrine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Pigmentation Skin Development Positive Regulation Of Cell Size Elastic Fiber Assembly Lung Alveolus Development Neuron Projection Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Positive Regulation Of Oxidoreductase Activity Elastin Biosynthetic Process Copper Ion Export Cellular Response To Amino Acid Stimulus Cellular Response To Antibiotic Cellular Response To Cadmium Ion Cellular Response To Cobalt Ion Cellular Response To Copper Ion Cellular Response To Iron Ion Cellular Response To Lead Ion Cellular Response To Hypoxia Divalent Inorganic Cation Transport Positive Regulation Of Response To Wounding Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Cytochrome-c Oxidase Activity
Pathways		Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases
Drugs		Cisplatin Sucrose Benzamidine
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Distal hereditary motor neuropathies (dHMN) Menkes disease (MD); Menkes kinky hair syndrome Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Systolic blood pressure change trajectories ( 27980656)	Height ( 31562340)
Interacting Genes		6 interacting genes: ATP7A ATP7B CFAP410 FAM118A FKBP4 GGPS1	3 interacting genes: ATOX1 CP PDZD11
Entrez ID		475	538
HPRD ID		03779	02054
Ensembl ID		ENSG00000177556	ENSG00000165240
Uniprot IDs		O00244	B4DRW0 Q04656 Q762B6
PDB IDs		1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L	1AW0 1KVI 1KVJ 1Q8L 1S6O 1S6U 1Y3J 1Y3K 1YJR 1YJT 1YJU 1YJV 2AW0 2G9O 2GA7 2K1R 2KIJ 2KMV 2KMX 3CJK 5T7L
Enriched GO Terms of Interacting Partners?
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