ATOX1 and GGPS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ATOX1	GGPS1
Description		antioxidant 1 copper chaperone	geranylgeranyl diphosphate synthase 1
Image
GO Annotations	Cellular Component	Cell Cytosol	Cytosol
	Molecular Function	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding ATPase Binding	Dimethylallyltranstransferase Activity Farnesyltranstransferase Activity Geranyltranstransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress Negative Regulation Of Apoptotic Process Copper Ion Export	Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Geranyl Diphosphate Biosynthetic Process Geranylgeranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process
Pathways		Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Cisplatin Sucrose Benzamidine	Zoledronic acid Geranyl Diphosphate FARNESYL THIOPYROPHOSPHATE ISOPENTENYL PYROPHOSPHATE (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)
Diseases
GWAS		Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Systolic blood pressure change trajectories ( 27980656)	Asthma ( 29273806)
Interacting Genes		6 interacting genes: ATP7A ATP7B CFAP410 FAM118A FKBP4 GGPS1	1 interacting genes: ATOX1
Entrez ID		475	9453
HPRD ID		03779	06099
Ensembl ID		ENSG00000177556	ENSG00000152904
Uniprot IDs		O00244	O95749
PDB IDs		1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L	2Q80 6C56 6C57 6G31 6G32 6R4V
Enriched GO Terms of Interacting Partners?
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