DLG5 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 12657639)
14

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DLG5	SORBS3
Description		discs large MAGUK scaffold protein 5	sorbin and SH3 domain containing 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Adherens Junction Postsynaptic Density Cell Junction Ciliary Basal Body	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Receptor Signaling Complex Scaffold Activity	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Epithelial To Mesenchymal Transition Signal Transduction Negative Regulation Of Cell Proliferation Maintenance Of Cell Polarity Negative Regulation Of Cell Migration Polarized Epithelial Cell Differentiation Midbrain Development Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Synapse Assembly Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Protein Localization To Adherens Junction Metanephric Collecting Duct Development Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS		Alanine transaminase levels ( 29403010) Gamma glutamyl transferase levels ( 29403010) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macular thickness ( 30535121) Obesity-related traits ( 23251661)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		8 interacting genes: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1	46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		9231	10174
HPRD ID		04972	11535
Ensembl ID		ENSG00000151208	ENSG00000120896
Uniprot IDs		Q8TDM6	O60504
PDB IDs		1UIT	2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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