SORBS3 and INPPL1

Number of citations of the paper that reports this interaction (PubMedID 16302969)
9

Data Source:
HPRD (two hybrid, in vivo)

		SORBS3	INPPL1
Description		sorbin and SH3 domain containing 3	inositol polyphosphate phosphatase like 1
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GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Nucleus Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Lamellipodium Filopodium
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	Actin Binding Protein Binding Hydrolase Activity SH3 Domain Binding SH2 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Endochondral Ossification Immune System Process Glucose Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Response To Insulin Inositol Phosphate Metabolic Process Phosphatidylinositol Dephosphorylation Ruffle Assembly
Pathways		Smooth Muscle Contraction	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Heart rate response to recovery post exercise (10 sec) ( 29497042)
Interacting Genes		46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	17 interacting genes: ABL1 ARAP3 BCAR1 CBL CD4 CSF1R EGFR FCGR2B FLNC HID1 HYOU1 MET SHC1 SORBS1 SORBS3 SRC UBC
Entrez ID		10174	3636
HPRD ID		11535	02900
Ensembl ID		ENSG00000120896	ENSG00000165458
Uniprot IDs		O60504	O15357
PDB IDs		2CT3 2DLM 2NWM 2YUP	2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP
Enriched GO Terms of Interacting Partners?
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