EIF2B3 and EIF2S2

Number of citations of the paper that reports this interaction (PubMedID 16288713)
3

Data Source:
HPRD (in vitro)

		EIF2B3	EIF2S2
Description		eukaryotic translation initiation factor 2B subunit gamma	eukaryotic translation initiation factor 2 subunit beta
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Guanyl-nucleotide Exchange Factor Complex	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Nucleotidyltransferase Activity	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Metal Ion Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Hippocampus Development Response To Peptide Hormone T Cell Receptor Signaling Pathway	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Male Germ Cell Proliferation Translational Initiation Male Gonad Development Transmembrane Transport
Pathways		Recycling of eIF2:GDP	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS			Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)
Interacting Genes		5 interacting genes: EIF2S1 EIF2S2 GOLM1 NDUFB8 STC2	24 interacting genes: AAR2 APLP1 APP CCDC90B CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16
Entrez ID		8891	8894
HPRD ID		09379	04882
Ensembl ID		ENSG00000070785	ENSG00000125977
Uniprot IDs		Q9HA31 Q9NR50	P20042 Q6IBR8
PDB IDs		6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z	6K71 6K72
Enriched GO Terms of Interacting Partners?
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