EIF2S2 and EIF4G2

Number of citations of the paper that reports this interaction (PubMedID 16932749)
32

Data Source:
HPRD (in vivo, in vitro)

		EIF2S2	EIF4G2
Description		eukaryotic translation initiation factor 2 subunit beta	eukaryotic translation initiation factor 4 gamma 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Metal Ion Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Male Germ Cell Proliferation Translational Initiation Male Gonad Development Transmembrane Transport	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Cellular Macromolecule Biosynthetic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)	Metabolite levels ( 23823483)
Interacting Genes		24 interacting genes: AAR2 APLP1 APP CCDC90B CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	11 interacting genes: CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL
Entrez ID		8894	1982
HPRD ID		04882	09084
Ensembl ID		ENSG00000125977	ENSG00000110321
Uniprot IDs		P20042 Q6IBR8	P78344 Q2TU89
PDB IDs		6K71 6K72	3D3M 3L6A 4IUL
Enriched GO Terms of Interacting Partners?
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