TNFSF13 and TNFRSF13B

Number of citations of the paper that reports this interaction (PubMedID 10956646)
49

Data Source:
HPRD (in vitro)

		TNFSF13	TNFRSF13B
Description		TNF superfamily member 13	TNF receptor superfamily member 13B
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Immune Response Signal Transduction Positive Regulation Of Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Isotype Switching To IgA Isotypes	B Cell Homeostasis Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 22864923 28628107) IgA nephropathy ( 26028593 25305756 22197929) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 22558069 29403010) Serum total protein level ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Albumin-globulin ratio ( 29403010) Diabetic retinopathy ( 21441570) Granulocyte percentage of myeloid white cells ( 27863252) Hematological and biochemical traits ( 20139978) Hematology traits ( 23303382) IgG levels ( 22673310) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte counts ( 27863252) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Multiple myeloma ( 26007630 23955597) Multiple myeloma and monoclonal gammopathy ( 26007630) Non-albumin protein levels ( 22558069 29403010) Platelet count ( 27863252) Plateletcrit ( 27863252) Serum albumin level ( 29403010) Serum total protein level ( 23022100 29403010) Sodium levels ( 29403010) Tonsillectomy ( 27182965 28928442)
Interacting Genes		12 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B	7 interacting genes: CAMLG SGTA TNFSF13 TNFSF13B TRAF2 TRAF5 TRAF6
Entrez ID		8741	23495
HPRD ID		05128	05365
Ensembl ID		ENSG00000161955	ENSG00000240505
Uniprot IDs		B3KR02 O75888 Q2QBA2	O14836 Q4ACX1
PDB IDs		4ZCH	1XU1 1XUT
Enriched GO Terms of Interacting Partners?
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