TNFSF13 and TNFRSF11B

Number of citations of the paper that reports this interaction (PubMedID 10706119)
26

Data Source:
HPRD (in vitro)

		TNFSF13	TNFRSF11B
Description		TNF superfamily member 13	TNF receptor superfamily member 11b
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Cytokine Activity Protein Binding Signaling Receptor Activity
	Biological Process	Immune Response Signal Transduction Positive Regulation Of Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Isotype Switching To IgA Isotypes	Skeletal System Development Apoptotic Process Signal Transduction Response To Nutrient Extracellular Matrix Organization Response To Magnesium Ion Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Estrogen Negative Regulation Of Bone Resorption Response To Arsenic-containing Substance
Pathways		HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases			Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 22864923 28628107) IgA nephropathy ( 26028593 25305756 22197929) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 22558069 29403010) Serum total protein level ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Asthma ( 29273806) Asthma (childhood onset) ( 30929738) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Bone mineral density ( 24249740 18455228 23437003) Bone mineral density (hip) ( 27311723 19801982) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Eosinophil counts ( 27863252) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Osteoporosis-related phenotypes ( 20548944) Osteoprotegerin levels ( 25080503) Serum alkaline phosphatase levels ( 31666285 29403010) Serum sclerostin levels ( 31170332) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 21980299)
Interacting Genes		12 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B	7 interacting genes: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF
Entrez ID		8741	4982
HPRD ID		05128	04032
Ensembl ID		ENSG00000161955	ENSG00000164761
Uniprot IDs		B3KR02 O75888 Q2QBA2	O00300
PDB IDs		4ZCH	3URF
Enriched GO Terms of Interacting Partners?
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