EED and PRDM14

Number of citations of the paper that reports this interaction (PubMedID 23280602)
27

Data Source:
BioGRID (pull down)

		EED	PRDM14
Description		embryonic ectoderm development	PR/SET domain 14
Image			No pdb structure
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Cytosol ESC/E(Z) Complex Pronucleus	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Protein Binding Nucleosome Binding Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H3-K27 Specific)	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Methyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Viral Process Spinal Cord Development Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Oligodendrocyte Differentiation Positive Regulation Of Histone H3-K27 Methylation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Germ Cell Development Embryo Implantation Fertilization Germ-line Stem Cell Population Maintenance Histone H3-R26 Methylation Somatic Stem Cell Population Maintenance Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of DNA Methylation Homeostasis Of Number Of Cells Within A Tissue Inactivation Of Paternal X Chromosome Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events	Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Schizophrenia ( 30285260) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		39 interacting genes: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42	32 interacting genes: AKAP9 ATPAF2 BAG4 BCAR3 BEX2 CASP8 CDCA7L CHEK2 DGCR6 EED EIF4E2 ERBB2 EZH2 GPATCH2L HEXIM2 HSPB7 ID3 IDH1 MIA3 NDUFB9 PALB2 PAX2 PLEKHF2 PRKAB2 PSMA1 PTPRJ RAD51D RBM10 RCOR3 SUZ12 TEKT4 TTC32
Entrez ID		8726	63978
HPRD ID		09343	11457
Ensembl ID		ENSG00000074266	ENSG00000147596
Uniprot IDs		E9PJK2 O75530	Q9GZV8
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6SFB 6SFC
Enriched GO Terms of Interacting Partners?
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