PRDM14 and IDH1

Number of citations of the paper that reports this interaction (PubMedID 27229929)
3

Data Source:
BioGRID (two hybrid)

		PRDM14	IDH1
Description		PR/SET domain 14	isocitrate dehydrogenase (NADP(+)) 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Methyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Identical Protein Binding Protein Homodimerization Activity Cadherin Binding NADP Binding NAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Germ Cell Development Embryo Implantation Fertilization Germ-line Stem Cell Population Maintenance Histone H3-R26 Methylation Somatic Stem Cell Population Maintenance Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of DNA Methylation Homeostasis Of Number Of Cells Within A Tissue Inactivation Of Paternal X Chromosome Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome NADP Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Neutrophil Degranulation Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process
Pathways		Transcriptional regulation of pluripotent stem cells	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import
Drugs			Isocitric Acid 2'-Monophosphoadenosine 5'-Diphosphoribose
Diseases
GWAS		Schizophrenia ( 30285260) Testicular germ cell tumor ( 28604728 28604732 23666240)	Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)
Interacting Genes		32 interacting genes: AKAP9 ATPAF2 BAG4 BCAR3 BEX2 CASP8 CDCA7L CHEK2 DGCR6 EED EIF4E2 ERBB2 EZH2 GPATCH2L HEXIM2 HSPB7 ID3 IDH1 MIA3 NDUFB9 PALB2 PAX2 PLEKHF2 PRKAB2 PSMA1 PTPRJ RAD51D RBM10 RCOR3 SUZ12 TEKT4 TTC32	14 interacting genes: AGGF1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 LAX1 NUP62 PEX5 PRDM14 SUMO4 TMOD4 UBL7 ZHX1
Entrez ID		63978	3417
HPRD ID		11457	00984
Ensembl ID		ENSG00000147596	ENSG00000138413
Uniprot IDs		Q9GZV8	A0A024R3Y6 O75874
PDB IDs			1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F
Enriched GO Terms of Interacting Partners?
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