PTCH2 and DHH

Number of citations of the paper that reports this interaction (PubMedID 9811851)
54

Data Source:
HPRD (in vivo)

		PTCH2	DHH
Description		patched 2	desert hedgehog signaling molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Space Plasma Membrane
	Molecular Function	Smoothened Binding Hedgehog Receptor Activity Hedgehog Family Protein Binding	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding
	Biological Process	Regulation Of Cell Growth Cell Fate Determination Smoothened Signaling Pathway Epidermal Cell Fate Specification Hair Cycle Skin Development Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway	Osteoblast Differentiation Cell Fate Specification Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Spermatid Development Regulation Of Gene Expression Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Response To Estrogen Regulation Of Steroid Biosynthetic Process
Pathways		Class B/2 (Secretin family receptors)	Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V abrogates palmitoylation of Hh-Np
Drugs
Diseases		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome	46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Intraocular pressure ( 30591961)	Bipolar disorder ( 31043756) Body mass index ( 25673413) Lumbar spine bone mineral density ( 22504420)
Interacting Genes		4 interacting genes: DHH IHH SHH SMO	3 interacting genes: HHIP PTCH1 PTCH2
Entrez ID		8643	50846
HPRD ID		04722	05664
Ensembl ID		ENSG00000117425	ENSG00000139549
Uniprot IDs		Q9Y6C5	O43323
PDB IDs			2WFQ 2WFR 2WG3 3N1G 3N1Q
Enriched GO Terms of Interacting Partners?
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