DHH and PTCH2

Number of citations of the paper that reports this interaction (PubMedID 9811851)
54

Data Source:
HPRD (in vivo)

		DHH	PTCH2
Description		desert hedgehog signaling molecule	patched 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding	Smoothened Binding Hedgehog Receptor Activity Hedgehog Family Protein Binding
	Biological Process	Osteoblast Differentiation Cell Fate Specification Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Spermatid Development Regulation Of Gene Expression Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Response To Estrogen Regulation Of Steroid Biosynthetic Process	Regulation Of Cell Growth Cell Fate Determination Smoothened Signaling Pathway Epidermal Cell Fate Specification Hair Cycle Skin Development Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway
Pathways		Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V abrogates palmitoylation of Hh-Np	Class B/2 (Secretin family receptors)
Drugs
Diseases		46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD	Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
GWAS		Bipolar disorder ( 31043756) Body mass index ( 25673413) Lumbar spine bone mineral density ( 22504420)	Intraocular pressure ( 30591961)
Interacting Genes		3 interacting genes: HHIP PTCH1 PTCH2	4 interacting genes: DHH IHH SHH SMO
Entrez ID		50846	8643
HPRD ID		05664	04722
Ensembl ID		ENSG00000139549	ENSG00000117425
Uniprot IDs		O43323	Q9Y6C5
PDB IDs		2WFQ 2WFR 2WG3 3N1G 3N1Q
Enriched GO Terms of Interacting Partners?
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