DHH

Description		desert hedgehog signaling molecule
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding
	Biological Process	Osteoblast Differentiation Cell Fate Specification Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Spermatid Development Regulation Of Gene Expression Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Response To Estrogen Regulation Of Steroid Biosynthetic Process
Pathways		Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V abrogates palmitoylation of Hh-Np
Drugs
Diseases		46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Bipolar disorder ( 31043756) Body mass index ( 25673413) Lumbar spine bone mineral density ( 22504420)
Interacting Genes		3 interacting genes: HHIP PTCH1 PTCH2
Entrez ID		50846
HPRD ID		05664
Ensembl ID		ENSG00000139549
Uniprot IDs		O43323
PDB IDs		2WFQ 2WFR 2WG3 3N1G 3N1Q
Enriched GO Terms of Interacting Partners?
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