DHH and HHIP

Number of citations of the paper that reports this interaction (PubMedID 10050855)
207

Data Source:
HPRD (in vivo)

		DHH	HHIP
Description		desert hedgehog signaling molecule	hedgehog interacting protein
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane	Extracellular Region Nucleus Cytoplasm Integral Component Of Plasma Membrane Cell Surface Ciliary Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding	Catalytic Activity Protein Binding Zinc Ion Binding Hedgehog Family Protein Binding
	Biological Process	Osteoblast Differentiation Cell Fate Specification Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Spermatid Development Regulation Of Gene Expression Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Response To Estrogen Regulation Of Steroid Biosynthetic Process	Signal Transduction Neuroblast Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Smoothened Signaling Pathway Skeletal System Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V abrogates palmitoylation of Hh-Np	Ligand-receptor interactions
Drugs
Diseases		46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Bipolar disorder ( 31043756) Body mass index ( 25673413) Lumbar spine bone mineral density ( 22504420)	Adolescent idiopathic scoliosis ( 30395268) Birth weight ( 31043758 27680694) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 25673413) Chronic obstructive pulmonary disease ( 22080838 28166215 30804561 19300482 25101718 20173748) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Daytime sleep phenotypes ( 27126917) Diverticular disease ( 30177863) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 30172743) Femoral neck size ( 31053729) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Infant length ( 25281659) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 31453325) Lung function (FEV1/FVC) variance ( 31453325) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Offspring birth weight ( 31043758) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pre bronchodilator FEV1/FVC ratio in never-smokers ( 27612410) Pulmonary function ( 20010834 20010835 19300500) Pulmonary function (smoking interaction) ( 23284291) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		3 interacting genes: HHIP PTCH1 PTCH2	3 interacting genes: DHH IHH SHH
Entrez ID		50846	64399
HPRD ID		05664	06937
Ensembl ID		ENSG00000139549	ENSG00000164161
Uniprot IDs		O43323	Q96QV1
PDB IDs		2WFQ 2WFR 2WG3 3N1G 3N1Q	2WFT 2WFX 2WG3 2WG4 3HO3 3HO4 3HO5
Enriched GO Terms of Interacting Partners?
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