AKR7A2 and TRIM63

Number of citations of the paper that reports this interaction (PubMedID 15967462)
98

Data Source:
BioGRID (two hybrid)

		AKR7A2	TRIM63
Description		aldo-keto reductase family 7 member A2	tripartite motif containing 63
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GO Annotations	Cellular Component	Golgi Apparatus Cytosol Extracellular Exosome	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Protein Binding Electron Transfer Activity Phenanthrene-9,10-epoxide Hydrolase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding
	Biological Process	Carbohydrate Metabolic Process Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Electron Transport Chain Daunorubicin Metabolic Process Doxorubicin Metabolic Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1
Pathways		Aflatoxin activation and detoxification	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		5 interacting genes: AKR7A3 EMC1 F2 MCPH1 TRIM63	93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		8574	84676
HPRD ID		04567	05843
Ensembl ID		ENSG00000053371	ENSG00000158022
Uniprot IDs		B4DZX4 O43488 V9HWA2	Q969Q1
PDB IDs		2BP1	2D8U 3DDT 4M3L
Enriched GO Terms of Interacting Partners?
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