TRIM63 and MYH6

Number of citations of the paper that reports this interaction (PubMedID 23695783)
9

Data Source:
BioGRID (enzymatic study)

		TRIM63	MYH6
Description		tripartite motif containing 63	myosin heavy chain 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Stress Fiber Cytosol Muscle Myosin Complex Myosin Complex Myofibril Sarcomere Z Disc Myosin Filament
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding	Microfilament Motor Activity Calmodulin Binding ATP Binding ATPase Activity Myosin Phosphatase Activity Protein Kinase Binding Actin-dependent ATPase Activity Actin Filament Binding
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1	In Utero Embryonic Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Protein Dephosphorylation Muscle Contraction Striated Muscle Contraction Adult Heart Development Visceral Muscle Development Regulation Of Heart Contraction Regulation Of Blood Pressure Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Myofibril Assembly Regulation Of ATPase Activity Sarcomere Organization ATP Metabolic Process Cardiac Muscle Fiber Development Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Regulation Of Heart Growth
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS			Aortic coarctation ( 29590334) Atrial fibrillation ( 30061737) Diastolic blood pressure ( 30578418) Electrocardiographic traits ( 20062063) Heart rate ( 23583979) P wave duration ( 28794112) P wave terminal force ( 28794112) PR interval ( 30046033) Pulse pressure ( 28135244 27618447 27618448 30578418) Resting heart rate ( 29769521 23183192 27798624 28270201 20639392) RR interval (heart rate) ( 30679814) Systolic blood pressure ( 27618447)
Interacting Genes		93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	6 interacting genes: CALCOCO1 CALCOCO2 ESR1 HSPB2 POLR2A TRIM63
Entrez ID		84676	4624
HPRD ID		05843	01171
Ensembl ID		ENSG00000158022	ENSG00000197616
Uniprot IDs		Q969Q1	P13533
PDB IDs		2D8U 3DDT 4M3L
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?