TRIM63 and DCAF6

Number of citations of the paper that reports this interaction (PubMedID 18157088)
67

Data Source:
BioGRID (two hybrid)

		TRIM63	DCAF6
Description		tripartite motif containing 63	DDB1 and CUL4 associated factor 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding	Protein Binding Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1	Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs
Diseases
GWAS			Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Schizophrenia ( 22037555)
Interacting Genes		93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	11 interacting genes: ACVR1 AR BMPR1B CUL4A GTF2IRD1 NR3C1 SMAD2 SUPT5H TGFBR1 TRIM55 TRIM63
Entrez ID		84676	55827
HPRD ID		05843	17156
Ensembl ID		ENSG00000158022	ENSG00000143164
Uniprot IDs		Q969Q1	Q58WW2
PDB IDs		2D8U 3DDT 4M3L	3I7O
Enriched GO Terms of Interacting Partners?
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