TRIM63 and UBE2U

Number of citations of the paper that reports this interaction (PubMedID 19690564)
57

Data Source:
BioGRID (two hybrid)

		TRIM63	UBE2U
Description		tripartite motif containing 63	ubiquitin conjugating enzyme E2 U
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Nuclear Chromatin HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Severe bacterial meningitis ( 31092817)
Interacting Genes		93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		84676	148581
HPRD ID		05843	14599
Ensembl ID		ENSG00000158022	ENSG00000177414
Uniprot IDs		Q969Q1	A0A140VJY9 Q5VVX9
PDB IDs		2D8U 3DDT 4M3L	1YRV
Enriched GO Terms of Interacting Partners?
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