SMARCA5 and POLE3

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical, pull down)

		SMARCA5	POLE3
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	DNA polymerase epsilon 3, accessory subunit
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Fibrillar Center Nucleus Nucleoplasm Chromatin Silencing Complex NURF Complex RSF Complex Nuclear Replication Fork	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex CHRAC
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity ATPase Activity Nucleosome Binding Histone Binding	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Silencing At RDNA Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription, Initiation Regulation Of Transcription By RNA Polymerase II Nucleosome Positioning CENP-A Containing Nucleosome Assembly ATP-dependent Chromatin Remodeling Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Leading Strand Elongation Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Semi-conservative Replication Nucleosome Mobilization Histone H3 Acetylation Heterochromatin Assembly Involved In Chromatin Silencing DNA Biosynthetic Process
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose	Cladribine
Diseases
GWAS		Height ( 31562340)
Interacting Genes		17 interacting genes: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B H3-3A H3C1 H4-16 HDAC2 MAF POLE3 RAD21 RSF1 SATB1	7 interacting genes: APP BAZ1A CHRAC1 DR1 DRAP1 POLE4 SMARCA5
Entrez ID		8467	54107
HPRD ID		04538	06274
Ensembl ID		ENSG00000153147	ENSG00000148229
Uniprot IDs		O60264	A0A024R829 Q9NRF9
PDB IDs		6NE3
Enriched GO Terms of Interacting Partners?
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