POLE3 and DR1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		POLE3	DR1
Description		DNA polymerase epsilon 3, accessory subunit	down-regulator of transcription 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex CHRAC	Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Negative Cofactor 2 Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Binding DNA Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Leading Strand Elongation Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Semi-conservative Replication Nucleosome Mobilization Histone H3 Acetylation Heterochromatin Assembly Involved In Chromatin Silencing DNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Histone H3 Acetylation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	HATs acetylate histones
Drugs		Cladribine
Diseases
GWAS			Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Metabolic syndrome ( 31589552) Triglyceride levels ( 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: APP BAZ1A CHRAC1 DR1 DRAP1 POLE4 SMARCA5	8 interacting genes: DNMT3L DRAP1 NFIL3 POLE3 TBP XPO1 YEATS2 ZDHHC17
Entrez ID		54107	1810
HPRD ID		06274	03284
Ensembl ID		ENSG00000148229	ENSG00000117505
Uniprot IDs		A0A024R829 Q9NRF9	Q01658 Q658N3
PDB IDs			1JFI
Enriched GO Terms of Interacting Partners?
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