CDC7 and GRHPR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CDC7	GRHPR
Description		cell division cycle 7	glyoxylate and hydroxypyruvate reductase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle	Cytoplasm Peroxisomal Matrix Cytosol Extracellular Exosome Catalytic Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding	Glycerate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Hydroxypyruvate Reductase Activity Glyoxylate Reductase (NADP) Activity Carboxylic Acid Binding Protein Homodimerization Activity NAD Binding NADPH Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Positive Regulation Of Cell Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division Negative Regulation Of G0 To G1 Transition	Excretion Cellular Nitrogen Compound Metabolic Process Dicarboxylic Acid Metabolic Process Glyoxylate Metabolic Process Oxidation-reduction Process
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6	Glyoxylate metabolism and glycine degradation
Drugs
Diseases			Primary hyperoxaluria (HP)
GWAS		Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Bipolar disorder ( 31043756) Chronotype ( 30696823) Morning person ( 30696823) Severe bacterial meningitis ( 31092817)
Interacting Genes		26 interacting genes: APP CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN CSDE1 DBF4 DBF4B DIAPH1 DTD1 GPT GRHPR MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC5 ORC6 TOB1	6 interacting genes: CDC7 FOS GLS2 LIG4 LSM1 PTH2R
Entrez ID		8317	9380
HPRD ID		10345	05052
Ensembl ID		ENSG00000097046	ENSG00000137106
Uniprot IDs		A0A384MTU6 B2R6V2 O00311	A0A384N605 Q9UBQ7
PDB IDs		4F99 4F9A 4F9B 4F9C 5UWQ 5UWR	2GCG 2H1S 2Q50 2WWR
Enriched GO Terms of Interacting Partners?
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