CDC7 and MCM10

Number of citations of the paper that reports this interaction (PubMedID 15232106)
123

Data Source:
HPRD (in vitro)

		CDC7	MCM10
Description		cell division cycle 7	minichromosome maintenance 10 replication initiation factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding	DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Positive Regulation Of Cell Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division Negative Regulation Of G0 To G1 Transition	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Proliferation
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		26 interacting genes: APP CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN CSDE1 DBF4 DBF4B DIAPH1 DTD1 GPT GRHPR MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC5 ORC6 TOB1	35 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 RECQL4 TNIP1 TRIM37 YWHAE ZBTB43 ZBTB8A
Entrez ID		8317	55388
HPRD ID		10345	11297
Ensembl ID		ENSG00000097046	ENSG00000065328
Uniprot IDs		A0A384MTU6 B2R6V2 O00311	Q7L590
PDB IDs		4F99 4F9A 4F9B 4F9C 5UWQ 5UWR
Enriched GO Terms of Interacting Partners?
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