WNT5A and FZD5

Number of citations of the paper that reports this interaction (PubMedID 9054360)
127

Data Source:
HPRD (in vivo)

		WNT5A	FZD5
Description		Wnt family member 5A	frizzled class receptor 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Clathrin-coated Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Postsynapse Glutamatergic Synapse	Golgi Membrane Plasma Membrane Integral Component Of Plasma Membrane Bicellular Tight Junction Cell Surface Integral Component Of Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perikaryon Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	DNA-binding Transcription Factor Activity Frizzled Binding Receptor Tyrosine Kinase-like Orphan Receptor Binding Cytokine Activity Protein Binding Phospholipid Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding Receptor Ligand Activity Chemoattractant Activity Involved In Axon Guidance	Amyloid-beta Binding G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity Protein-containing Complex Binding
	Biological Process	Activation Of MAPK Activity Establishment Of Planar Polarity Somitogenesis Epithelial To Mesenchymal Transition Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Cytokine Secretion Involved In Immune Response Primary Heart Field Specification Secondary Heart Field Specification Atrial Septum Development Type B Pancreatic Cell Development Planar Cell Polarity Pathway Involved In Axis Elongation Optic Cup Formation Involved In Camera-type Eye Development Wnt Signaling Pathway, Calcium Modulating Pathway Activation Of JUN Kinase Activity Axon Guidance Hindgut Morphogenesis Midgut Development Male Gonad Development Anterior/posterior Axis Specification, Embryo Response To Organic Substance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Olfactory Bulb Interneuron Development Neuron Differentiation Keratinocyte Differentiation Lung Development Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Activation Of Protein Kinase B Activity Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Chemoattraction Of Serotonergic Neuron Axon Chemorepulsion Of Dopaminergic Neuron Axon Non-canonical Wnt Signaling Pathway Via JNK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Embryonic Digit Morphogenesis Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Chemokine Biosynthetic Process Cell Fate Commitment Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Ossification Positive Regulation Of Endocytosis Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Paraxial Mesoderm Formation Notochord Morphogenesis Embryonic Skeletal System Development Genitalia Development Negative Regulation Of Axon Extension Involved In Axon Guidance Hypophysis Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Synapse Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Positive Regulation Of Timing Of Anagen Negative Regulation Of Synapse Assembly Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Uterus Development Cervix Development Vagina Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Urinary Bladder Development Face Development Positive Regulation Of Type I Interferon-mediated Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Mesenchymal-epithelial Cell Signaling Negative Regulation Of Prostatic Bud Formation Mammary Gland Branching Involved In Thelarche Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Response To Cytokine Stimulus Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Planar Cell Polarity Pathway Involved In Gastrula Mediolateral Intercalation Mesodermal To Mesenchymal Transition Involved In Gastrulation Positive Regulation Of Macrophage Cytokine Production Membrane Organization Positive Regulation Of Cartilage Development Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Secondary Palate Development Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Retinoic Acid Cellular Response To Interferon-gamma Hematopoietic Stem Cell Proliferation Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Mesenchymal Cell Proliferation Primitive Streak Formation Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Activation Of GTPase Activity Melanocyte Proliferation Presynapse Assembly Postsynapse Assembly Regulation Of Postsynapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Neuron Death Positive Regulation Of Protein Localization To Synapse Regulation Of Cellular Protein Localization Positive Regulation Of Tumor Necrosis Factor Secretion Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Cell Proliferation In Midbrain Planar Cell Polarity Pathway Involved In Axon Guidance Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Planar Cell Polarity Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Interleukin-8 Secretion	Embryonic Axis Specification Angiogenesis Positive Regulation Of T Cell Cytokine Production G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Synapse Assembly Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Interleukin-1 Beta Secretion Spemann Organizer Formation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor Secretion Beta-catenin Destruction Complex Disassembly Regulation Of Bicellular Tight Junction Assembly
Pathways		TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 RNF mutants show enhanced WNT signaling and proliferation
Drugs
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Height ( 28552196) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Type 2 diabetes ( 30130595)
Interacting Genes		3 interacting genes: FZD1 FZD5 ROR2	11 interacting genes: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 UBTD1 WNT5A WNT7A
Entrez ID		7474	7855
HPRD ID		01293	03427
Ensembl ID		ENSG00000114251	ENSG00000163251
Uniprot IDs		A0A024R316 A0A384N611 B3KQX9 P41221	Q13467
PDB IDs			5URY 5URZ 6O39
Enriched GO Terms of Interacting Partners?
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