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FZD5 and RPS6KA6
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
114
Data Source:
BioGRID
(two hybrid)
FZD5
RPS6KA6
Description
frizzled class receptor 5
ribosomal protein S6 kinase A6
Image
GO Annotations
Cellular Component
Golgi Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Bicellular Tight Junction
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Clathrin-coated Endocytic Vesicle Membrane
Early Endosome Membrane
Perikaryon
Synapse
Perinuclear Region Of Cytoplasm
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Molecular Function
Amyloid-beta Binding
G Protein-coupled Receptor Activity
Protein Binding
Lipid Binding
Wnt-protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Wnt-activated Receptor Activity
Protein-containing Complex Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
ATP Binding
Biological Process
Embryonic Axis Specification
Angiogenesis
Positive Regulation Of T Cell Cytokine Production
G Protein-coupled Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Synapse Assembly
Negative Regulation Of Cell Proliferation
Anterior/posterior Axis Specification, Embryo
Neuron Differentiation
Post-embryonic Camera-type Eye Development
Positive Regulation Of Interferon-gamma Production
T Cell Differentiation In Thymus
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Cell Maturation
Embryonic Camera-type Eye Morphogenesis
Positive Regulation Of Interleukin-1 Beta Secretion
Spemann Organizer Formation
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Apoptotic Process Involved In Morphogenesis
Branching Involved In Labyrinthine Layer Morphogenesis
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Labyrinthine Layer Blood Vessel Development
Chorionic Trophoblast Cell Differentiation
Cellular Response To Molecule Of Bacterial Origin
Regulation Of Chorionic Trophoblast Cell Proliferation
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor Secretion
Beta-catenin Destruction Complex Disassembly
Regulation Of Bicellular Tight Junction Assembly
Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Signal Transduction
Central Nervous System Development
Intracellular Signal Transduction
Negative Regulation Of Embryonic Development
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Mesoderm Development
Pathways
Class B/2 (Secretin family receptors)
Ca2+ pathway
Ca2+ pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
RNF mutants show enhanced WNT signaling and proliferation
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Drugs
Diseases
GWAS
Interacting Genes
11 interacting genes:
ABI3BP
GOPC
GSK3B
LRP6
LZTFL1
RGS2
ROR2
RPS6KA6
UBTD1
WNT5A
WNT7A
27 interacting genes:
ADIRF
APP
CEBPZ
CENPB
CLEC3B
DHX34
DNAJC13
DNMT1
ERG28
FBN3
FZD5
LMO4
MASP1
MED24
MICAL1
MPP1
NR4A1
RBPJ
RPLP1
RXRA
SAP30BP
SPTBN4
SYNE4
UBE2I
UFM1
ZNF227
ZNF746
Entrez ID
7855
27330
HPRD ID
03427
02250
Ensembl ID
ENSG00000163251
ENSG00000072133
Uniprot IDs
Q13467
Q9UK32
PDB IDs
5URY
5URZ
6O39
6G76
6G77
6G78
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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