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WNT5A and ROR2
Number of citations of the paper that reports this interaction (PubMedID
12839624
)
233
Data Source:
HPRD
(in vitro)
WNT5A
ROR2
Description
Wnt family member 5A
receptor tyrosine kinase like orphan receptor 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Plasma Membrane
Cell Surface
Clathrin-coated Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Collagen-containing Extracellular Matrix
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Microtubule
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Axon
Dendrite
Clathrin-coated Endocytic Vesicle Membrane
Neuronal Cell Body
Receptor Complex
Molecular Function
DNA-binding Transcription Factor Activity
Frizzled Binding
Receptor Tyrosine Kinase-like Orphan Receptor Binding
Cytokine Activity
Protein Binding
Phospholipid Binding
Protein Domain Specific Binding
Transcription Regulatory Region DNA Binding
Receptor Ligand Activity
Chemoattractant Activity Involved In Axon Guidance
Transmembrane Receptor Protein Tyrosine Kinase Activity
Frizzled Binding
Protein Binding
ATP Binding
Wnt-protein Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Metal Ion Binding
Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
Biological Process
Activation Of MAPK Activity
Establishment Of Planar Polarity
Somitogenesis
Epithelial To Mesenchymal Transition
Positive Regulation Of Endothelial Cell Proliferation
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Cytokine Secretion Involved In Immune Response
Primary Heart Field Specification
Secondary Heart Field Specification
Atrial Septum Development
Type B Pancreatic Cell Development
Planar Cell Polarity Pathway Involved In Axis Elongation
Optic Cup Formation Involved In Camera-type Eye Development
Wnt Signaling Pathway, Calcium Modulating Pathway
Activation Of JUN Kinase Activity
Axon Guidance
Hindgut Morphogenesis
Midgut Development
Male Gonad Development
Anterior/posterior Axis Specification, Embryo
Response To Organic Substance
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Olfactory Bulb Interneuron Development
Neuron Differentiation
Keratinocyte Differentiation
Lung Development
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Binding
Activation Of Protein Kinase B Activity
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Protein Localization
Non-canonical Wnt Signaling Pathway
Post-anal Tail Morphogenesis
Chemoattraction Of Serotonergic Neuron Axon
Chemorepulsion Of Dopaminergic Neuron Axon
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Wound Healing
Embryonic Digit Morphogenesis
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Chemokine Biosynthetic Process
Cell Fate Commitment
Establishment Of Epithelial Cell Apical/basal Polarity
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Ossification
Positive Regulation Of Endocytosis
Positive Regulation Of Meiotic Nuclear Division
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Melanin Biosynthetic Process
Positive Regulation Of Fibroblast Proliferation
Paraxial Mesoderm Formation
Notochord Morphogenesis
Embryonic Skeletal System Development
Genitalia Development
Negative Regulation Of Axon Extension Involved In Axon Guidance
Hypophysis Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Interleukin-1 Beta Secretion
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Regulation Of Synapse Organization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cartilage Development
Positive Regulation Of Timing Of Anagen
Negative Regulation Of Synapse Assembly
Convergent Extension Involved In Axis Elongation
Convergent Extension Involved In Organogenesis
Uterus Development
Cervix Development
Vagina Development
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Urinary Bladder Development
Face Development
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis
Mesenchymal-epithelial Cell Signaling
Negative Regulation Of Prostatic Bud Formation
Mammary Gland Branching Involved In Thelarche
Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Positive Regulation Of Response To Cytokine Stimulus
Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
Planar Cell Polarity Pathway Involved In Gastrula Mediolateral Intercalation
Mesodermal To Mesenchymal Transition Involved In Gastrulation
Positive Regulation Of Macrophage Cytokine Production
Membrane Organization
Positive Regulation Of Cartilage Development
Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis
Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis
Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis
Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis
Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis
Secondary Palate Development
Positive Regulation Of Thymocyte Apoptotic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Calcium Ion
Cellular Response To Retinoic Acid
Cellular Response To Interferon-gamma
Hematopoietic Stem Cell Proliferation
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Mesenchymal Cell Proliferation
Primitive Streak Formation
Positive Regulation Of Protein Kinase C Signaling
Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Activation Of GTPase Activity
Melanocyte Proliferation
Presynapse Assembly
Postsynapse Assembly
Regulation Of Postsynapse Organization
Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Positive Regulation Of Neuron Projection Arborization
Positive Regulation Of Protein Kinase C Activity
Positive Regulation Of Neuron Death
Positive Regulation Of Protein Localization To Synapse
Regulation Of Cellular Protein Localization
Positive Regulation Of Tumor Necrosis Factor Secretion
Excitatory Synapse Assembly
Inhibitory Synapse Assembly
Negative Regulation Of Cell Proliferation In Midbrain
Planar Cell Polarity Pathway Involved In Axon Guidance
Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Planar Cell Polarity Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of Non-canonical Wnt Signaling Pathway
Positive Regulation Of Interleukin-8 Secretion
Cartilage Condensation
Somitogenesis
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Smoothened Signaling Pathway
JNK Cascade
Multicellular Organism Development
Nervous System Development
Negative Regulation Of Cell Proliferation
Positive Regulation Of Neuron Projection Development
Astrocyte Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Bone Mineralization
Positive Regulation Of Cell Migration
BMP Signaling Pathway
Embryonic Genitalia Morphogenesis
Male Genitalia Development
Positive Regulation Of Kinase Activity
Inner Ear Morphogenesis
Embryonic Digit Morphogenesis
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Cell Fate Commitment
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription, DNA-templated
Anatomical Structure Development
Positive Regulation Of Synaptic Transmission, Glutamatergic
Wnt Signaling Pathway, Planar Cell Polarity Pathway
SMAD Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Kinase C Activity
Macrophage Migration
Pathways
TCF dependent signaling in response to WNT
TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking
WNT ligand biogenesis and trafficking
Class B/2 (Secretin family receptors)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Ca2+ pathway
Ca2+ pathway
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
PCP/CE pathway
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
Brachydactyly, including: type A; type B; type D; type E
Robinow syndrome
GWAS
Carboplatin disposition in epthelial ovarian cancer (
29367611
)
Height (
28552196
)
Lung function (FEV1/FVC) (
28166213
)
Metabolite levels (
23823483
)
Type 2 diabetes (
30130595
)
Bipolar disorder (inflammation and infection response interaction) (
25781172
)
Bipolar disorder and schizophrenia (
22688191
)
Birth weight (
31043758
)
Bone mineral density (hip) (
26911590
)
Facial morphology (
31763980
)
Iris color (L* coordinate) (
30895295
)
Nose size (
27182965
)
Offspring birth weight (
31043758
)
Type 2 diabetes (
25483131
)
Interacting Genes
3 interacting genes:
FZD1
FZD5
ROR2
43 interacting genes:
C1orf94
CDC14A
CDC25C
CRX
DAB1
DAZAP2
DUPD1
DUSP1
DUSP10
DUSP14
DUSP18
DUSP19
DUSP21
DUSP6
ERBB2
EYA2
FZD2
FZD5
IKBKG
ILKAP
MAGED1
MAP3K7
MTMR1
MTMR2
MTMR6
MTMR9
PPM1A
PPM1B
PPM1F
PPP3CB
PRR20A
PTPN11
PTPN12
PTPN20
PTPN6
PTPN7
PTPRR
RBPMS
STYX
TAB1
TPTE
WNT5A
ZMYM4
Entrez ID
7474
4920
HPRD ID
01293
03822
Ensembl ID
ENSG00000114251
ENSG00000169071
Uniprot IDs
A0A024R316
A0A384N611
B3KQX9
P41221
Q01974
PDB IDs
3ZZW
4GT4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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