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FZD5 and LZTFL1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
75
Data Source:
BioGRID
(two hybrid)
FZD5
LZTFL1
Description
frizzled class receptor 5
leucine zipper transcription factor like 1
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Bicellular Tight Junction
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Clathrin-coated Endocytic Vesicle Membrane
Early Endosome Membrane
Perikaryon
Synapse
Perinuclear Region Of Cytoplasm
Cytosol
Molecular Function
Amyloid-beta Binding
G Protein-coupled Receptor Activity
Protein Binding
Lipid Binding
Wnt-protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Wnt-activated Receptor Activity
Protein-containing Complex Binding
Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Embryonic Axis Specification
Angiogenesis
Positive Regulation Of T Cell Cytokine Production
G Protein-coupled Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Synapse Assembly
Negative Regulation Of Cell Proliferation
Anterior/posterior Axis Specification, Embryo
Neuron Differentiation
Post-embryonic Camera-type Eye Development
Positive Regulation Of Interferon-gamma Production
T Cell Differentiation In Thymus
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Cell Maturation
Embryonic Camera-type Eye Morphogenesis
Positive Regulation Of Interleukin-1 Beta Secretion
Spemann Organizer Formation
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Apoptotic Process Involved In Morphogenesis
Branching Involved In Labyrinthine Layer Morphogenesis
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Labyrinthine Layer Blood Vessel Development
Chorionic Trophoblast Cell Differentiation
Cellular Response To Molecule Of Bacterial Origin
Regulation Of Chorionic Trophoblast Cell Proliferation
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor Secretion
Beta-catenin Destruction Complex Disassembly
Regulation Of Bicellular Tight Junction Assembly
Negative Regulation Of Protein Localization To Cilium
Negative Regulation Of Protein Localization To Ciliary Membrane
Pathways
Class B/2 (Secretin family receptors)
Ca2+ pathway
Ca2+ pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
RNF mutants show enhanced WNT signaling and proliferation
BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS
Acne (severe) (
24927181
)
Methadone dose in opioid dependence (
28115739
)
Multiple sclerosis (
31604244
)
Interacting Genes
11 interacting genes:
ABI3BP
GOPC
GSK3B
LRP6
LZTFL1
RGS2
ROR2
RPS6KA6
UBTD1
WNT5A
WNT7A
3 interacting genes:
FZD5
NTAQ1
SDCBP
Entrez ID
7855
54585
HPRD ID
03427
07586
Ensembl ID
ENSG00000163251
ENSG00000163818
Uniprot IDs
Q13467
Q9NQ48
PDB IDs
5URY
5URZ
6O39
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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