UCHL1 and NEDD8

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UCHL1	NEDD8
Description		ubiquitin C-terminal hydrolase L1	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm	Cell Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding
	Biological Process	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Proliferation Regulation Of Macroautophagy Protein Deubiquitination Sensory Perception Of Pain Axonal Transport Of Mitochondrion Cellular Response To Drug Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Muscle Fiber Development Neuromuscular Process	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Iron Ion Homeostasis Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Protein Deubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Post-translational Protein Modification Protein Neddylation
Pathways		UCH proteinases	TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs		Phenethyl Isothiocyanate
Diseases		Parkinson's disease (PD)
GWAS		Cognitive performance ( 19734545) Metabolite levels ( 23823483)	Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PLA2G2A PRKN RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28	42 interacting genes: AHR ARIH2 ATE1 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		7345	4738
HPRD ID		01877	04412
Ensembl ID		ENSG00000154277	ENSG00000129559
Uniprot IDs		P09936 V9HW74	Q15843
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F
Enriched GO Terms of Interacting Partners?
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