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NEDD8 and CUL1
Number of citations of the paper that reports this interaction (PubMedID
10713156
)
135
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, in vitro)
NEDD8
CUL1
Description
NEDD8 ubiquitin like modifier
cullin 1
Image
GO Annotations
Cellular Component
Cell
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Exosome
Cell
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Protein Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Cellular Protein Modification Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Cellular Iron Ion Homeostasis
Protein Localization
Anatomical Structure Morphogenesis
Response To Organic Cyclic Compound
Protein Ubiquitination
Protein Deubiquitination
Modification-dependent Protein Catabolic Process
Regulation Of Proteolysis
Post-translational Protein Modification
Protein Neddylation
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Iron Ion Homeostasis
Cell Proliferation
Animal Organ Morphogenesis
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
TGF-beta receptor signaling activates SMADs
UCH proteinases
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Iron uptake and transport
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK - noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Mean corpuscular volume (
29403010
)
Systolic blood pressure (cigarette smoking interaction) (
26752167
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Interacting Genes
42 interacting genes:
AHR
ARIH2
ATE1
ATXN3
CBLB
CDC34
COPS5
COPS6
CTRC
CUL1
CUL2
CUL3
CUL4B
DNMT3B
GARS1
GHR
HGS
HIF1A
N4BP1
NAE1
NUB1
OTUB1
OTUD5
PARP1
POLI
PSMA6
PSMD4
PTK2
RAD23A
SENP8
SMURF1
TP53
UBA2
UBA3
UBE2K
UBE2M
UBL7
UBQLN1
UBXN7
UCHL1
UCHL3
YAF2
57 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CDKN1B
CENPE
CENPW
CHEK1
CHUK
CKS1B
COMMD1
COPS2
COPS5
COPS6
COPS8
DLEU2
E2F1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
GHR
GPS1
HIPK2
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
Entrez ID
4738
8454
HPRD ID
04412
04389
Ensembl ID
ENSG00000129559
ENSG00000055130
Uniprot IDs
Q15843
A0A090N7U0
B3KTW0
Q13616
PDB IDs
1NDD
1R4M
1R4N
1XT9
2BKR
2KO3
2N7K
2NVU
3DBH
3DBL
3DBR
3DQV
3GZN
4F8C
4FBJ
4HCP
4P5O
6R7F
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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