C4BPB and PROS1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (unspecified method, affinity chromatography technology)
HPRD (in vitro)

		C4BPB	PROS1
Description		complement component 4 binding protein beta	protein S
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding	Endopeptidase Inhibitor Activity Calcium Ion Binding
	Biological Process	Complement Activation, Classical Pathway Blood Coagulation Response To Symbiotic Bacterium Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Leukocyte Migration
Pathways		Regulation of Complement cascade	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade
Drugs		Zinc	Drotrecogin alfa Menadione Sodium Tetradecyl Sulfate
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency	Inherited thrombophilia
GWAS		C4b binding protein levels ( 20212171) Hip circumference ( 28552196)	Systemic lupus erythematosus ( 28714469)
Interacting Genes		1 interacting genes: PROS1	10 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3
Entrez ID		725	5627
HPRD ID		00404	01473
Ensembl ID		ENSG00000123843	ENSG00000184500
Uniprot IDs		P20851	A0A0S2Z4K3 A0A0S2Z4L3 P07225
PDB IDs			1Z6C
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?