ABCC8 and KCNJ8

Number of citations of the paper that reports this interaction (PubMedID 11160857)
30

Data Source:
HPRD (in vitro)

		ABCC8	KCNJ8
Description		ATP binding cassette subfamily C member 8	potassium inwardly rectifying channel subfamily J member 8
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Potassium Ion-transporting ATPase Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Potassium Ion-transporting ATPase Complex
	Molecular Function	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase Activity Cation-transporting ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding	Inward Rectifier Potassium Channel Activity ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Cation-transporting ATPase Activity Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Potassium Ion Transport Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Potassium Ion Import Across Plasma Membrane
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypoglycemias and hyperglycemias	ATP sensitive Potassium channels
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glycodiazine	Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Birth weight ( 31043758)
Interacting Genes		4 interacting genes: CRYBB1 ENSA KCNJ11 KCNJ8	4 interacting genes: ABCC8 ABCC9 KCNJ11 KCNJ2
Entrez ID		6833	3764
HPRD ID		02741	02962
Ensembl ID		ENSG00000006071	ENSG00000121361
Uniprot IDs		Q09428	A0A024RAV6 Q15842
PDB IDs		6C3O 6C3P
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?