KCNJ8 and ABCC8

Number of citations of the paper that reports this interaction (PubMedID 11160857)
30

Data Source:
HPRD (in vitro)

		KCNJ8	ABCC8
Description		potassium inwardly rectifying channel subfamily J member 8	ATP binding cassette subfamily C member 8
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Potassium Ion-transporting ATPase Complex	Plasma Membrane Inward Rectifying Potassium Channel Membrane Potassium Ion-transporting ATPase Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Cation-transporting ATPase Activity Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase Activity Cation-transporting ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Potassium Ion Import Across Plasma Membrane	Potassium Ion Transport Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		ATP sensitive Potassium channels	ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypoglycemias and hyperglycemias
Drugs		Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine	ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glycodiazine
Diseases			Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Birth weight ( 31043758)	Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		4 interacting genes: ABCC8 ABCC9 KCNJ11 KCNJ2	4 interacting genes: CRYBB1 ENSA KCNJ11 KCNJ8
Entrez ID		3764	6833
HPRD ID		02962	02741
Ensembl ID		ENSG00000121361	ENSG00000006071
Uniprot IDs		A0A024RAV6 Q15842	Q09428
PDB IDs			6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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