ABCC8 and CRYBB1

Number of citations of the paper that reports this interaction (PubMedID 12941953)
55

Data Source:
HPRD (in vivo)

		ABCC8	CRYBB1
Description		ATP binding cassette subfamily C member 8	crystallin beta B1
Image
GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Potassium Ion-transporting ATPase Complex
	Molecular Function	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase Activity Cation-transporting ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding	Structural Constituent Of Eye Lens Protein Binding
	Biological Process	Potassium Ion Transport Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport	Lens Development In Camera-type Eye Visual Perception
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypoglycemias and hyperglycemias
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glycodiazine
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: CRYBB1 ENSA KCNJ11 KCNJ8	6 interacting genes: ABCC8 CRYBA1 CRYBA2 CRYBA4 TERF1 TERF2IP
Entrez ID		6833	1414
HPRD ID		02741	09021
Ensembl ID		ENSG00000006071	ENSG00000100122
Uniprot IDs		Q09428	P53674
PDB IDs		6C3O 6C3P	1OKI
Enriched GO Terms of Interacting Partners?
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