SLC5A2 and AQP2

Number of citations of the paper that reports this interaction (PubMedID 28931009)
7

Data Source:
BioGRID (two hybrid)

		SLC5A2	AQP2
Description		solute carrier family 5 member 2	aquaporin 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	Low-affinity Glucose:sodium Symporter Activity Glucose:sodium Symporter Activity	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity
	Biological Process	Carbohydrate Metabolic Process Sodium Ion Transport Hexose Transmembrane Transport Glucose Transmembrane Transport	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		Cellular hexose transport Defective SLC5A2 causes renal glucosuria (GLYS1)	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs		Dapagliflozin Canagliflozin Empagliflozin
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		1 interacting genes: AQP2	25 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CERT1 CLDN7 CREB3 EEF1A1 ELL2 ERG28 GPAA1 IER3 NDFIP2 PLP2 SLC5A2 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM230 UBE2J1 VAPB
Entrez ID		6524	359
HPRD ID		08919	00141
Ensembl ID		ENSG00000140675	ENSG00000167580
Uniprot IDs		P31639	P41181
PDB IDs			4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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