AQP2 and IER3

Number of citations of the paper that reports this interaction (PubMedID 28931009)
7

Data Source:
BioGRID (two hybrid)

		AQP2	IER3
Description		aquaporin 2	immediate early response 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Nucleus Cytosol Integral Component Of Membrane
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity	Protein Binding
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development	Apoptotic Process Anatomical Structure Morphogenesis Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Apoptotic Process Regulation Of Response To DNA Damage Stimulus
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)	Age-related macular degeneration ( 23455636) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Chronic obstructive pulmonary disease ( 30804561) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sleep duration ( 25469926) Small cell lung carcinoma ( 28604730) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476)
Interacting Genes		25 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CERT1 CLDN7 CREB3 EEF1A1 ELL2 ERG28 GPAA1 IER3 NDFIP2 PLP2 SLC5A2 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM230 UBE2J1 VAPB	10 interacting genes: APP AQP2 FHL2 GLP1R MAPK1 MAPK3 MDM2 PPP2R5B PPP2R5C PRNP
Entrez ID		359	8870
HPRD ID		00141	04295
Ensembl ID		ENSG00000167580	ENSG00000137331
Uniprot IDs		P41181	A0A1U9X7X2 P46695
PDB IDs		4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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