AQP2 and NDFIP2

Number of citations of the paper that reports this interaction (PubMedID 28931009)
7

Data Source:
BioGRID (two hybrid)

		AQP2	NDFIP2
Description		aquaporin 2	Nedd4 family interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity	Protein Binding WW Domain Binding
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development	Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Protein Transport
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)	Leisure-time exercise behaviour (age-stratified) ( 30102679) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Pancreatic cancer ( 20686608) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		25 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CERT1 CLDN7 CREB3 EEF1A1 ELL2 ERG28 GPAA1 IER3 NDFIP2 PLP2 SLC5A2 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM230 UBE2J1 VAPB	12 interacting genes: ALKBH2 AQP2 ITCH LYN NEDD4 NEDD4L POU4F1 RBM26 SLITRK6 SMURF1 SPRY2 WWP2
Entrez ID		359	54602
HPRD ID		00141	17629
Ensembl ID		ENSG00000167580	ENSG00000102471
Uniprot IDs		P41181	B4DGY6 Q9NV92
PDB IDs		4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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