ARAP3 and SH3KBP1

Number of citations of the paper that reports this interaction (PubMedID 17314030)
15

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ARAP3	SH3KBP1
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	SH3 domain containing kinase binding protein 1
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GO Annotations	Cellular Component	Ruffle Cytosol Cytoskeleton Plasma Membrane Lamellipodium	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding	Protein Binding SH3 Domain Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization
Pathways		Rho GTPase cycle	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)
Interacting Genes		10 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 TNKS2	44 interacting genes: ABI2 ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 UBB UBC UBE2I ZBTB7B ZNF219
Entrez ID		64411	30011
HPRD ID		09441	02301
Ensembl ID		ENSG00000120318	ENSG00000147010
Uniprot IDs		Q05CH1 Q8WWN8 Q9H7C1	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		2KG5 2LNW 5JCP 5JD0	2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS
Enriched GO Terms of Interacting Partners?
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