SH3KBP1 and TJP2

Number of citations of the paper that reports this interaction (PubMedID 12829691)
19

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		SH3KBP1	TJP2
Description		SH3 domain containing kinase binding protein 1	tight junction protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse	Nucleus Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cell-cell Contact Zone
	Molecular Function	Protein Binding SH3 Domain Binding	Guanylate Kinase Activity Protein Binding Protein Domain Specific Binding Protein Binding, Bridging Cadherin Binding Protein Tyrosine Kinase Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization	Homotypic Cell-cell Adhesion Hippo Signaling GMP Metabolic Process GDP Metabolic Process Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Positive Regulation Of Maintenance Of Permeability Of Blood-brain Barrier
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Signaling by Hippo Apoptotic cleavage of cell adhesion proteins
Drugs
Diseases
GWAS			Macular thickness ( 30535121) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 23396134) Renal sinus fat ( 22044751) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		44 interacting genes: ABI2 ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 UBB UBC UBE2I ZBTB7B ZNF219	17 interacting genes: CDK6 CGN CLDN1 CLDN2 CLK1 CTNNA1 EPB41 HGS HSPB1 SAFB SCRIB SH3KBP1 SRPK2 TJP1 YWHAB YWHAG YWHAZ
Entrez ID		30011	9414
HPRD ID		02301	06369
Ensembl ID		ENSG00000147010	ENSG00000119139
Uniprot IDs		B7Z6E8 Q5JPT6 Q96B97	B7Z2R3 B7Z954 Q9UDY2
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	2OSG 3E17
Enriched GO Terms of Interacting Partners?
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