AKTIP and VPS16

Number of citations of the paper that reports this interaction (PubMedID 18799622)
41

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		AKTIP	VPS16
Description		AKT interacting protein	VPS16 core subunit of CORVET and HOPS complexes
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane HOPS Complex FHF Complex	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Clathrin-coated Vesicle Axon HOPS Complex Late Endosome Membrane Neuronal Cell Body Recycling Endosome
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Apoptotic Process Cellular Response To DNA Damage Stimulus Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport	Intracellular Protein Transport Vacuole Organization Endosome To Lysosome Transport Endosomal Transport Regulation Of Vacuole Fusion, Non-autophagic Regulation Of SNARE Complex Assembly Autophagosome Maturation
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Metabolite levels ( 23823483)
Interacting Genes		26 interacting genes: AKT1 ASS1 CEP126 CTBP2 DZIP3 EXOC7 FAM160A2 GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MARCHF5 MATR3 PDPK1 POLA2 RPA1 TRIM23 TRIM41 TWNK UTP14A VPS16 VPS18 VPS41	14 interacting genes: AKTIP FBXO7 HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP STX1A STX7 UVRAG VPS11 VPS18 VPS33A
Entrez ID		64400	64601
HPRD ID		07467	12259
Ensembl ID		ENSG00000166971	ENSG00000215305
Uniprot IDs		A0A024R6S6 A0A024R6T5 Q9H8T0	Q9H269
PDB IDs			4BX9
Enriched GO Terms of Interacting Partners?
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