CARD9 and TCL1A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CARD9	TCL1A
Description		caspase recruitment domain family member 9	T cell leukemia/lymphoma 1A
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Nucleoplasm Endoplasmic Reticulum Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Protein Homodimerization Activity CARD Domain Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Fungus Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Exogenous DsRNA Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Defense Response To Virus	Multicellular Organism Development Positive Regulation Of Cell Proliferation Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 23749187 21743469) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 21102463) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Ulcerative colitis ( 19915572 28067908 20228799 21297633)	Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		69 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 C2CD6 CCDC85B CCHCR1 CDCA7L CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DUSP13 DVL2 EIF4E2 FAM124B FAM161A FAM50B HMBOX1 IHO1 IQCE KCTD9 KIAA0408 KIF9 KRT19 KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 LENG1 LMO1 LZTS2 MEOX2 MFAP1 NECAB2 PAK5 PBX2 PHC2 PNMA5 PPP1R18 RTP5 SSX2IP STX11 SUMO1 TASOR2 TCEANC TCL1A TFIP11 TLE5 TNFAIP1 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSNAX USP15 VPS28 ZCCHC7 ZNF250 ZNF417 ZNF572 ZNF587 ZNF655 ZNF688	23 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CEP55 DNMT3A FLACC1 GOLGA2 H2AW LNX2 LSM3 NTAQ1 PRTFDC1 TCF4 TP53BP2 TRAF1 TTC33 TXLNA TXLNB WDR47
Entrez ID		64170	8115
HPRD ID		06236	01744
Ensembl ID		ENSG00000187796	ENSG00000100721
Uniprot IDs		A0A024R8F1 Q9H257	A0A024R6G5 P56279
PDB IDs		6E25 6E26 6E27 6E28 6N2M 6N2P	1JSG
Enriched GO Terms of Interacting Partners?
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