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CARD9 and AMOTL2
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
381
Data Source:
BioGRID
(two hybrid)
CARD9
AMOTL2
Description
caspase recruitment domain family member 9
angiomotin like 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Protein-containing Complex
Cytosol
Plasma Membrane
Bicellular Tight Junction
Apical Plasma Membrane
Cytoplasmic Vesicle
Recycling Endosome
Molecular Function
Protein Binding
Protein Homodimerization Activity
CARD Domain Binding
Protein Binding
Identical Protein Binding
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Response To Fungus
Response To Peptidoglycan
Response To Muramyl Dipeptide
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Exogenous DsRNA
Regulation Of Interleukin-2 Biosynthetic Process
Innate Immune Response
Regulation Of Interleukin-6 Biosynthetic Process
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Defense Response To Virus
Angiogenesis
Establishment Of Cell Polarity Involved In Ameboidal Cell Migration
Wnt Signaling Pathway
Actin Cytoskeleton Organization
Regulation Of Cell Migration
Hippo Signaling
Pathways
NOD1/2 Signaling Pathway
CLEC7A (Dectin-1) signaling
Signaling by Hippo
Drugs
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS
Acute insulin response (insulin secretion adjusted) (
28490609
)
Ankylosing spondylitis (
23749187
21743469
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
22936669
21102463
)
IgA nephropathy (
25305756
)
Inflammatory bowel disease (
28067908
23128233
)
Joint damage in rheumatoid arthritis (
26498133
)
Large artery stroke (
28265093
)
Monocyte chemoattractant protein-1 levels (
23017229
)
Obesity-related traits (
23251661
)
Pediatric autoimmune diseases (
26301688
)
Ulcerative colitis (
19915572
28067908
20228799
21297633
)
Cadmium levels (
26025379
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Interacting Genes
69 interacting genes:
ABLIM1
AMOTL2
AXIN1
BCL10
BLZF1
C1orf94
C2CD6
CCDC85B
CCHCR1
CDCA7L
CEP57L1
CEP70
CSNK2A1
CWF19L2
DAXX
DUSP13
DVL2
EIF4E2
FAM124B
FAM161A
FAM50B
HMBOX1
IHO1
IQCE
KCTD9
KIAA0408
KIF9
KRT19
KRT31
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-5
LENG1
LMO1
LZTS2
MEOX2
MFAP1
NECAB2
PAK5
PBX2
PHC2
PNMA5
PPP1R18
RTP5
SSX2IP
STX11
SUMO1
TASOR2
TCEANC
TCL1A
TFIP11
TLE5
TNFAIP1
TRIM23
TRIM29
TRIM42
TRIM54
TRIM62
TSNAX
USP15
VPS28
ZCCHC7
ZNF250
ZNF417
ZNF572
ZNF587
ZNF655
ZNF688
57 interacting genes:
BLZF1
BRMS1L
CARD9
CCHCR1
CDR2
CHCHD3
CYTH4
DDIT3
DYNLL1
EIF4E2
FAM184A
FBXO7
FXR2
GCC1
GNG11
GNG5
GOLGA2
GSTM5
KRT13
KRT15
KRT19
KRT20
KRT31
KRT38
KRTAP10-5
KRTAP4-2
LMO4
MAD1L1
MAGEA4
MAGOHB
MFAP1
MPP1
MTMR6
MTNR1A
MYO5B
NDC80
NFIL3
NTAQ1
PSMC3
RAD51D
RALBP1
RASSF5
RNF20
RNF40
SH3RF2
SMARCE1
SP100
SPAG5
SPOP
SPP1
THRA
TMCC2
TNKS2
TRAF2
TRIM27
ZBED1
ZGPAT
Entrez ID
64170
51421
HPRD ID
06236
16485
Ensembl ID
ENSG00000187796
ENSG00000114019
Uniprot IDs
A0A024R8F1
Q9H257
Q9Y2J4
PDB IDs
6E25
6E26
6E27
6E28
6N2M
6N2P
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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