SH2D4A and ALAS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SH2D4A	ALAS1
Description		SH2 domain containing 4A	5'-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Protein Binding Phosphatase Binding Signaling Adaptor Activity	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Signal Transduction Negative Regulation Of Phosphatase Activity	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process
Pathways			Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs			Pyridoxal Phosphate Pyridoxal Phosphate Glycine
Diseases
GWAS		Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		44 interacting genes: ALAS1 CASK CCDC172 CDR2 CEP70 CEP76 DBNL FSD2 GOLGA2 GRB2 HCLS1 HMBOX1 IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PNMA1 PPP1CB PSTPIP1 RINT1 SH3GL1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 UBXN11 USHBP1 VPS52 ZBTB16	39 interacting genes: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK EP400 GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B RTL8B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		63898	211
HPRD ID		08340	00505
Ensembl ID		ENSG00000104611	ENSG00000023330
Uniprot IDs		Q9H788	B4DVA0 P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?
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