ALAS1 and POLDIP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		ALAS1	POLDIP2
Description		5'-aminolevulinate synthase 1	DNA polymerase delta interacting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nucleus Mitochondrion Mitochondrial Nucleoid
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	DNA Binding Protein Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process	Negative Regulation Of Macroautophagy Positive Regulation Of Mitotic Cell Cycle Mitochondrion Morphogenesis
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs		Pyridoxal Phosphate Pyridoxal Phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Blood protein levels ( 29875488) Osteoprotegerin levels ( 25080503)
Interacting Genes		39 interacting genes: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK EP400 GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B RTL8B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	17 interacting genes: ALAS1 APP ASCC2 CPE FBXO7 HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN PTEN REV1 SELENBP1 TAB1 TMEM97
Entrez ID		211	26073
HPRD ID		00505	17874
Ensembl ID		ENSG00000023330	ENSG00000004142
Uniprot IDs		B4DVA0 P13196 Q5JAM2	B4DEM9 Q9Y2S7
PDB IDs
Enriched GO Terms of Interacting Partners?
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