RALA and GCK

		RALA	GCK
Description		RAS like proto-oncogene A	glucokinase
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Exosome Flemming Body	Cell Nucleoplasm Mitochondrion Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding	Glucokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity
	Biological Process	Neural Tube Closure Exocytosis Chemotaxis Cell Cycle Signal Transduction Ras Protein Signal Transduction Regulation Of Exocytosis Actin Cytoskeleton Reorganization Interleukin-12-mediated Signaling Pathway Cell Division Positive Regulation Of Filopodium Assembly Membrane Raft Localization Membrane Organization	Cellular Glucose Homeostasis Glycolytic Process Regulation Of Glycolytic Process NADP Metabolic Process Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Glucose Homeostasis Regulation Of Potassium Ion Transport Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Detection Of Glucose Canonical Glycolysis Calcium Ion Import
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane p38MAPK events Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Regulation of Glucokinase by Glucokinase Regulatory Protein Regulation of gene expression in beta cells Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Guanosine-5'-Diphosphate	Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases			Maturity onset diabetes of the young (MODY) Permanent neonatal diabetes mellitus (PNDM)
GWAS			Birth weight ( 31043758 27680694) Blood sugar levels ( 29403010) Coronary artery disease and triglyceride levels (multivariate analysis) ( 30525989) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 19060907) Glycated hemoglobin levels ( 24647736 20858683 24244560 31213470 19096518 28898252) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Hemoglobin A1c levels ( 29403010) Homeostasis model assessment of beta-cell function ( 20081858) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Offspring birth weight ( 31043758 29309628) Pulse pressure ( 27841878 30578418) Triglycerides ( 30275531) Type 2 diabetes ( 22885922 30297969 30718926)
Interacting Genes		36 interacting genes: ACTB AKAP10 ARF1 C1QC CALM1 CNKSR2 CTCF EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA GCK GLS2 HOXA2 HSPB1 INHBA LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RASSF5 REPS1 RGL2 RGL4 SMAD4 YBX3	6 interacting genes: GCKR INS PCNA PFKFB2 PFKFB3 RALA
Entrez ID		5898	2645
HPRD ID		01549	00680
Ensembl ID		ENSG00000006451	ENSG00000106633
Uniprot IDs		P11233	P35557 Q53Y25
PDB IDs		1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV	1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I
Enriched GO Terms of Interacting Partners?
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