GCK and GCKR

Number of citations of the paper that reports this interaction (PubMedID 10601273)
41

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GCK	GCKR
Description		glucokinase	glucokinase regulator
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Glucokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Carbohydrate Binding Fructose-6-phosphate Binding
	Biological Process	Cellular Glucose Homeostasis Glycolytic Process Regulation Of Glycolytic Process NADP Metabolic Process Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Glucose Homeostasis Regulation Of Potassium Ion Transport Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Detection Of Glucose Canonical Glycolysis Calcium Ion Import	Carbohydrate Metabolic Process Regulation Of Glycolytic Process Protein Import Into Nucleus Response To Fructose Negative Regulation Of Glucokinase Activity Glucose Homeostasis Urate Metabolic Process Triglyceride Homeostasis Carbohydrate Derivative Metabolic Process
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein Regulation of gene expression in beta cells Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Drugs		Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases		Maturity onset diabetes of the young (MODY) Permanent neonatal diabetes mellitus (PNDM)
GWAS		Birth weight ( 31043758 27680694) Blood sugar levels ( 29403010) Coronary artery disease and triglyceride levels (multivariate analysis) ( 30525989) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 19060907) Glycated hemoglobin levels ( 24647736 20858683 24244560 31213470 19096518 28898252) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Hemoglobin A1c levels ( 29403010) Homeostasis model assessment of beta-cell function ( 20081858) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Offspring birth weight ( 31043758 29309628) Pulse pressure ( 27841878 30578418) Triglycerides ( 30275531) Type 2 diabetes ( 22885922 30297969 30718926)	Albumin-globulin ratio ( 29403010) Alcohol consumption ( 27911795 28937693 31358974) Alcohol consumption (drinks per week) ( 28485404 30643258 30679032) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Bitter beverage consumption ( 31046077) Blood glucose levels ( 29615537) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels in cardiovascular risk ( 28369058) Blood sugar levels ( 29403010) Branched-chain amino acid levels (Isoleucine) ( 27898682) Branched-chain amino acid levels (Leucine) ( 27898682) Branched-chain amino acid levels (Valine) ( 27898682) Breast size ( 22747683) C-reactive protein ( 18439548) C-reactive protein levels ( 29403010 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Calcium levels ( 24068962 20705733) Cardiovascular disease risk factors ( 21943158) Chloride levels ( 29403010) Cholesterol, total ( 24097068 25961943 20686565 26582766) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic kidney disease ( 29124443 20383146) circulating leptin levels ( 26833098) circulating leptin levels adjusted for BMI ( 26833098) Coffee consumption ( 31046077) Coffee consumption (cups per day) ( 25288136) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Crohn's disease ( 28067908 21102463) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood insulin ( 25631608 20081858 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting blood insulin adjusted for BMI ( 25625282) Fasting plasma glucose ( 25187374 28270201 22508271) Gallstone disease ( 30504769 27094239) Gamma glutamyl transferase levels ( 29403010) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Gondoic acid (20:1n-9) levels ( 28298293) Gout ( 25646370 31578528 27899376) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25282103 31562340) Hematocrit ( 27863252) Hematological and biochemical traits ( 20139978) High light scatter reticulocyte percentage of red cells ( 27863252) Homeostasis model assessment of insulin resistance ( 20081858) Hypertriglyceridemia ( 31910446 27599772 23505323 20657596) Inflammatory bowel disease ( 28067908) Kidney stones ( 31729369) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 18179892 30275531) Lipid metabolism phenotypes ( 19936222) Lipid traits ( 24386095 24023260) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Lymphocyte counts ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910 21886157) Metabolite levels ( 21909109 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Non-albumin protein levels ( 22558069) Nonalcoholic fatty liver disease ( 29385134) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Percent glycated albumin ( 29844224) Phospholipid levels (plasma) ( 22359512) Plasma lactate levels ( 26433129) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet count ( 22139419 29403010 27863252) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein C levels ( 28082259) Prothrombin time ( 29403010) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Renal overload gout ( 27899376) Renal underexcretion gout ( 27899376) Resting heart rate ( 29769521 27798624) Serum albumin level ( 23022100 29403010) Serum alkaline phosphatase levels ( 31666285) Serum alpha1-antitrypsin levels ( 26174136) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271) Serum total protein level ( 23022100 29403010) Serum uric acid levels ( 30993211 29403010) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total body bone mineral density ( 29304378) Total cholesterol levels ( 28334899 29403010 29615537 30275531) Triglyceride levels ( 30718733 28334899 31647587 30911093 29403010 29615537) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 23726366 24097068 29404214 21909109 18193043 18193044 20864672 26160806 19060906 19060911 20139978 30275531 17463246 25961943 26780889 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 28566273 22885922 30054458 30297969 29632382 26818947 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 20884846 31578528 20139978 23263486) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary sodium excretion ( 31409800) Urinary sodium to creatinine ratio ( 30910378) Urolithiasis ( 30975718) Waist Circumference - Triglycerides (WC-TG) ( 21386085) Waist circumference and related phenotypes ( 18454146) White blood cell count ( 29403010 27863252 24777453)
Interacting Genes		6 interacting genes: GCKR INS PCNA PFKFB2 PFKFB3 RALA	6 interacting genes: ATP5MG CDKN1A CSDE1 EP300 GCK TRAF2
Entrez ID		2645	2646
HPRD ID		00680	02909
Ensembl ID		ENSG00000106633	ENSG00000084734
Uniprot IDs		P35557 Q53Y25	A0A0C4DFN2 Q14397
PDB IDs		1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I	4BB9 4BBA 4LY9 4MQU 4MRO 4MSU 4OHK 4OHM 4OHO 4OHP 4OLH 4OP1 4OP2 4OP3 4PX2 4PX3 4PX5 4PXS
Enriched GO Terms of Interacting Partners?
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