EPS15L1 and FCHO2

Number of citations of the paper that reports this interaction (PubMedID 27237791)
24

Data Source:
BioGRID (pull down)

		EPS15L1	FCHO2
Description		epidermal growth factor receptor pathway substrate 15 like 1	FCH and mu domain containing endocytic adaptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Membrane Clathrin Coat Of Coated Pit	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle Presynaptic Endocytic Zone Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Cadherin Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization	Membrane Invagination Clathrin Coat Assembly Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Eosinophil percentage of granulocytes ( 27863252) Lymphocyte counts ( 29403010 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 22190364 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) White blood cell count ( 27863252 21738480) White matter integrity ( 23218918)	Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 29403010) Discordance in emotional problems in monozygotic twins ( 27043157) Eyebrow thickness ( 26926045) Factor VIII levels ( 30586737) Heel bone mineral density ( 30598549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Monobrow thickness ( 26926045) Non-albumin protein levels ( 29403010) Red cell distribution width ( 27863252) Serum albumin level ( 29403010) Small cell lung carcinoma ( 28604730) vWF levels ( 30586737)
Interacting Genes		12 interacting genes: AGFG1 AGFG2 EPN1 FCHO1 FCHO2 GNG5 ITSN1 ITSN2 SGIP1 STON2 TRAPPC2B UBC	7 interacting genes: DAB2 EPS15 EPS15L1 ITSN1 MRPS27 RHOU UBC
Entrez ID		58513	115548
HPRD ID		09445	13319
Ensembl ID		ENSG00000127527	ENSG00000157107
Uniprot IDs		A0A024R7G6 Q9UBC2	Q0JRZ9
PDB IDs			2V0O
Enriched GO Terms of Interacting Partners?
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