HES4 and PCBD1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		HES4	PCBD1
Description		hes family bHLH transcription factor 4	pterin-4 alpha-carbinolamine dehydratase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Factor Binding Protein Dimerization Activity E-box Binding N-box Binding	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Cell Differentiation Negative Regulation Of Neuron Differentiation	L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process
Pathways			Phenylalanine metabolism
Drugs			L-erythro-7,8-dihydrobiopterin
Diseases			Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS			Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)
Interacting Genes		5 interacting genes: COPG2 LTN1 PCBD1 PCBD2 RGS3	49 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 POLR3A RBL2 RPS24 SAP30 SCMH1 SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714
Entrez ID		57801	5092
HPRD ID		16273	00523
Ensembl ID		ENSG00000188290	ENSG00000166228
Uniprot IDs		D6REB3 E9PB28 Q9HCC6	P61457
PDB IDs
Enriched GO Terms of Interacting Partners?
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