HES4 and PCBD2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		HES4	PCBD2
Description		hes family bHLH transcription factor 4	pterin-4 alpha-carbinolamine dehydratase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Cellular_component Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Factor Binding Protein Dimerization Activity E-box Binding N-box Binding	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Cell Differentiation Negative Regulation Of Neuron Differentiation	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process
Pathways
Drugs
Diseases
GWAS			Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 28552196 18391951) Type 2 diabetes ( 24509480)
Interacting Genes		5 interacting genes: COPG2 LTN1 PCBD1 PCBD2 RGS3	33 interacting genes: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A F2RL1 FBXO7 GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3
Entrez ID		57801	84105
HPRD ID		16273	17824
Ensembl ID		ENSG00000188290	ENSG00000132570
Uniprot IDs		D6REB3 E9PB28 Q9HCC6	Q9H0N5
PDB IDs			4C45
Enriched GO Terms of Interacting Partners?
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