PTCH1 and DHH

Number of citations of the paper that reports this interaction (PubMedID 9811851)
54

Data Source:
HPRD (in vivo)

		PTCH1	DHH
Description		patched 1	desert hedgehog signaling molecule
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GO Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Caveola Postsynaptic Density Integral Component Of Membrane Midbody Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Ciliary Membrane	Extracellular Space Plasma Membrane
	Molecular Function	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein-containing Complex Binding Hedgehog Family Protein Binding	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Cell Fate Determination Neural Tube Closure Heart Morphogenesis Smoothened Signaling Pathway Regulation Of Mitotic Cell Cycle Brain Development Regulation Of Smoothened Signaling Pathway Response To Mechanical Stimulus Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Epidermal Cell Fate Specification Response To Chlorate Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Prostate Gland Development Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Keratinocyte Proliferation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Embryonic Organ Development Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Commissural Neuron Axon Guidance Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Protein Localization To Plasma Membrane Liver Regeneration	Osteoblast Differentiation Cell Fate Specification Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Spermatid Development Regulation Of Gene Expression Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Response To Estrogen Regulation Of Steroid Biosynthetic Process
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Hedgehog 'on' state Activation of SMO	Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V abrogates palmitoylation of Hh-Np
Drugs
Diseases		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome Holoprosencephaly (HPE) Basal cell carcinoma	46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adventurousness ( 30643258) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 26733130) Bone mineral density (spine) ( 26733130) Dental caries (decayed, missing and filled teeth) ( 31533690) Feeling hurt ( 29500382) Feeling worry ( 29500382) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 25429064 31562340 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Monobrow ( 27182965) Neurociticism ( 29500382) Nonsyndromic cleft lip with cleft palate ( 28232668) Offspring birth weight ( 31043758) Optic disc size ( 31809533) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Bipolar disorder ( 31043756) Body mass index ( 25673413) Lumbar spine bone mineral density ( 22504420)
Interacting Genes		11 interacting genes: ATG101 ATM CCNB1 CDK1 CREB3 DHH HIPK2 IHH SHH SMO YAP1	3 interacting genes: HHIP PTCH1 PTCH2
Entrez ID		5727	50846
HPRD ID		03200	05664
Ensembl ID		ENSG00000185920	ENSG00000139549
Uniprot IDs		Q13635	O43323
PDB IDs		6DMB 6DMO 6DMY 6E1H 6N7G 6N7H 6N7K 6OEU 6OEV 6RMG 6RTW 6RTX 6RTY 6RVC 6RVD	2WFQ 2WFR 2WG3 3N1G 3N1Q
Enriched GO Terms of Interacting Partners?
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