CEP55 and CDC45

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CEP55	CDC45
Description		centrosomal protein 55	cell division cycle 45
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GO Annotations	Cellular Component	Cell Cytoplasm Centrosome Centriole Plasma Membrane Membrane Midbody Cleavage Furrow Centriolar Satellite Intercellular Bridge Flemming Body	Nucleus Nucleoplasm Nuclear Pre-replicative Complex Cytoplasm Centrosome DNA Replication Preinitiation Complex Replication Fork Protection Complex
	Molecular Function	Protein Binding Identical Protein Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Plate Congression Multicellular Organism Development Regulation Of Phosphatidylinositol 3-kinase Signaling Establishment Of Protein Localization Midbody Abscission Cranial Skeletal System Development	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Replication Preinitiation Complex Assembly
Pathways			Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)	Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		62 interacting genes: AKAP9 ANXA11 ARHGEF15 C1orf109 CCBE1 CCHCR1 CDC45 CDK1 CDSN CEP57L1 DTNB ECSIT EIF1AD FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS KIFC3 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NOS3 NTAQ1 PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RCOR3 RNF32 SDCBP SNRPB SNW1 SUPT5H TCL1A TEAD4 TEX11 TEX14 TFG TSG101 UBC VPS37C VPS37D WASHC3	23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 TOPBP1 TRAPPC3 UBC
Entrez ID		55165	8318
HPRD ID		12569	09145
Ensembl ID		ENSG00000138180	ENSG00000093009
Uniprot IDs		Q53EZ4	O75419
PDB IDs		3E1R 3WUT 3WUU 3WUV	5DGO
Enriched GO Terms of Interacting Partners?
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